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Updated: Jun 28, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
Published on: May 9, 2025
Synthetic soldiers: Turning T cells into immortal warriors
Nicholas P Restifo1,2, Luca Gattinoni3,4,5
1Marble Therapeutics , Boston, MA, USA.
None:
The creation of synthetic T cell states has captivated the field of cell-based therapies. Wang et al. (https://doi.org/10.1084/jem.20232368) describe how disruption of BCOR and ZC3H12A unleashes anti-tumor T cells with unprecedented lifespan and killer instinct. Are we witnessing the birth of immortal super-soldiers in medicine?
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