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Identity-by-descent analysis of sibship configurations
American Journal of Medical Genetics
|October 1, 1985
Abstract:
This study considers configurations of identity-by-descent sharing in sibships as an alternative to breaking the sibship into sib pairs. A general method is presented for specifying all distinct configurations and deriving their probabilities. The method works for sibships of arbitrary size and can be implemented with paper and pencil. Specific results are given for sibships up to size six. Applications for disease-marker studies are discussed.
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