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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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The Impact of Redosing Antibiotics for Pediatric Patients Undergoing Appendectomy for Complicated Appendicitis

Monique Motta1, Nikitha Garapaty2, Margaret Savage2

  • 1Department of Surgery, Memorial Healthcare System, Hollywood, FL, USA.

The American Surgeon
|April 18, 2024
PubMed

Insights

For pediatric appendectomy patients with complicated appendicitis, additional pre-operative antibiotic doses did not significantly reduce surgical site infection (SSI) rates. Current protocols may not require redosing antibiotics closer to incision time.

Area of Science:

  • Pediatric Surgery
  • Infectious Disease
  • Antibiotic Stewardship

Background:

  • Standardized pre-operative antibiotic protocols for pediatric appendectomy with complicated appendicitis are lacking.
  • Mitigating surgical site infections (SSIs) requires balancing effective antibiotic use with minimizing exposure.

Purpose of the Study:

  • To compare SSIs in pediatric patients undergoing laparoscopic appendectomy for complicated appendicitis who received a single pre-operative antibiotic dose versus those receiving additional doses.

Main Methods:

  • Retrospective chart review of 124 pediatric patients between 2020 and 2022.
  • Comparison of SSI rates between patients receiving one versus multiple pre-operative antibiotic doses.

Main Results:

  • 18% of patients received additional pre-operative antibiotic doses.
  • No statistically significant difference in SSI rates was observed between the groups (P-value = .352).

Conclusions:

  • Redosing antibiotics closer to incision time may not impact SSI rates in this patient population.
  • Further research is needed to establish definitive clinical recommendations for pre-operative antibiotic administration.

Keywords:
general surgerypediatric surgerysurgical infectionwound healing

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