Related Experiment Video
Updated: Jun 28, 2025
08:03
In Vivo Mouse Model of Spinal Implant Infection
Published on: June 23, 2020
2.3K
Mapping the risk factors, pathogens, and antibiotic of pharyngocutaneous fistula in patients after neck open surgery
Weili Kong1, Manlin Chen1, Hailing Gu1
1Department of Otolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Summary
Pharyngocutaneous fistula (PCF) risk factors after open neck surgery include flap reconstruction, prior radiotherapy, bleeding, and diabetes. Cefoperazone/sulbactam or ticarcillin/clavulanic acid are recommended empirical antibiotics for PCF.
Area of Science:
- Head and Neck Surgery
- Oncology
- Infectious Diseases
Background:
- Limited consensus exists on risk factors for pharyngocutaneous fistula (PCF).
- Empirical antibiotic guidelines for PCF are not well-established.
- Open neck surgery for laryngeal and hypopharyngeal cancer carries a risk of PCF.
Purpose of the Study:
- To identify clinical characteristics and risk factors associated with PCF after open neck surgery.
- To analyze pathogenic bacteria involved in PCF.
- To improve antibiotic treatment efficacy for PCF by assessing pathogen susceptibility.
Main Methods:
- Retrospective cohort study of 699 patients undergoing open neck surgery over 13 years.
- Logistic regression analysis to determine PCF risk factors.
- Microbial analysis and antibiotic susceptibility testing of top three pathogens.
Main Results:
- The incidence of PCF was 8%.
- Significant risk factors for PCF included flap reconstruction, preoperative radiotherapy, postoperative bleeding, and diabetes.
- Pseudomonas aeruginosa, Escherichia coli, and Enterobacter cloacae were the most common pathogens; cefepime, meropenem, ticarcillin/clavulanic acid, and cefoperazone/sulbactam showed 100% sensitivity.
Conclusions:
- Patients undergoing open neck surgery with risk factors like flap reconstruction, prior radiotherapy, bleeding, or diabetes require close monitoring for PCF.
- Empirical antibiotic therapy with cefoperazone/sulbactam or ticarcillin/clavulanic acid is recommended for PCF based on pathogen distribution and susceptibility.
- Strengthening monitoring and care is crucial for PCF prevention.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
01:23Chronic Pharyngitis
2.0K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
2.0K
01:20Infection
7.9K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.9K
01:30Acute Pharyngitis
624
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
624
01:26Tracheostomy Suctioning I: Pre-Procedural Steps
534
Tracheostomy suctioning is a critical procedure healthcare professionals perform to maintain a patent airway in patients with a tracheostomy tube. This procedure is necessary when secretions accumulate in the airway, causing respiratory distress. Here is a step-wise procedural guide for performing tracheostomy suctioning using an open system.
Equipment Required
First, gather all necessary equipment: a sterile suction catheter, a sterile disposable container, sterile gloves, a towel or...
Equipment Required
First, gather all necessary equipment: a sterile suction catheter, a sterile disposable container, sterile gloves, a towel or...
534
01:23Skin Diseases and Disorders
3.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.8K