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Current advances in human-induced pluripotent stem cell-based models and therapeutic approaches for congenital heart

Meiling Cao1, Yanshan Liu2, Ying Sun2

  • 1Department of Neonatology, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.

Molecular and Cellular Biochemistry
|April 18, 2024
PubMed

Insights

Induced pluripotent stem cells (iPSCs) offer new avenues for treating congenital heart disease (CHD). This review explores iPSC-based therapies, including exosome potential, and discusses clinical challenges for future CHD treatment.

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Stem Cell Biology

Background:

  • Congenital heart disease (CHD) significantly impacts neonatal survival and adult health.
  • Current therapeutic strategies for CHD have limitations.
  • Emerging technologies present novel treatment possibilities.

Purpose of the Study:

  • To review advancements in induced pluripotent stem cell (iPSC)-based models for CHD.
  • To elucidate potential therapeutic mechanisms, including exosome paracrine effects.
  • To delineate clinical constraints of iPSC-based therapies for CHD.

Main Methods:

  • Review of current literature on iPSC-based CHD research.
  • Analysis of technological integration (CRISPR, high-throughput screening, organoids).
  • Evaluation of exosome-mediated therapeutic potential.

Main Results:

  • iPSCs and derived cells show promise for CHD treatment.
  • CRISPR, high-throughput screening, and organoid technologies enhance CHD research.
  • Exosome paracrine effects represent a potential therapeutic avenue.

Conclusions:

  • iPSC-based approaches offer significant potential for CHD treatment.
  • Technological advancements are crucial for developing effective iPSC therapies.
  • Addressing clinical constraints is vital for successful iPSC-based CHD interventions.

Keywords:
Clinical trialsCongenital heart diseaseDisease modelingExosomesInduced pluripotent stem cellshiPSC therapy

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