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Osteosarcoma after the fourth decade. A clinico-pathological review.
Archives of Orthopaedic and Traumatic Surgery. Archiv Fur Orthopadische Und Unfall-Chirurgie
|January 1, 1985
Summary
Osteosarcoma is rare in adults over 40, with delayed referrals and misdiagnoses common in these older patients. This review examines the clinical and histological features of this patient group.
Area of Science:
- Oncology
- Orthopedic Surgery
- Pathology
Background:
- Osteosarcoma, a primary bone cancer, typically affects children and young adults.
- Adult-onset osteosarcoma (over 40) is uncommon, necessitating specific clinical and diagnostic considerations.
Purpose of the Study:
- To review the clinical presentation and histology of osteosarcoma in patients over 40.
- To identify diagnostic challenges and potential delays in this specific demographic.
Main Methods:
- Retrospective review of 160 osteosarcoma cases over 18 years.
- Analysis of clinical data and histological findings for patients aged over 40 at presentation.
Main Results:
- Eighteen out of 160 (11.25%) osteosarcoma cases occurred in patients over 40.
- Frequent delays in referral and incorrect initial histological diagnoses were noted.
- Only 2 cases (11.1% of the over-40 group) were associated with Paget's disease.
Conclusions:
- Osteosarcoma in older adults presents unique challenges, including diagnostic delays.
- Accurate and timely histological diagnosis is crucial for appropriate management of adult-onset osteosarcoma.
- While rare, osteosarcoma should be considered in the differential diagnosis of bone lesions in older individuals.