Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harnessing Immunogenic PANoptosis With Iridium(III) Biradical Photosensitizers for Melanoma Photoimmunotherapy.

Angewandte Chemie (International ed. in English)·2026
Same author

Synergistic Effect of Gradient Conductivity and Gradient Microstructures Enabled Ultrasensitive and Ultrabroad Linear Flexible Tactile Sensors.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Encapsulation of a ruthenium-platinum photosensitizer into nanofibrous membranes for antibacterial photodynamic therapy.

Journal of materials chemistry. B·2026
Same author

Corynoline and Extracellular Vesicles Co-Loaded Scaffold Accelerates Vascularized Bone Regeneration with Photothermal Stimulation.

ACS biomaterials science & engineering·2026
Same author

Immunologically Effective Chiral Polymers to Potentiate Anti-Cancer Immune Responses.

Polymer science & technology (Washington, D.C.)·2026
Same author

Synthetic Polymers for Drug, Gene, and Vaccine Delivery.

Polymer science & technology (Washington, D.C.)·2026

Related Experiment Video

Updated: Jun 28, 2025

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

360

Nanomedomics.

Ganghao Liang1,2, Wanqing Cao3,4, Dongsheng Tang1,2

  • 1Beijing National Laboratory for Molecular Sciences, Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.

ACS Nano
|April 18, 2024
PubMed
Summary

Understanding nanomedicine mechanisms is key for developing new treatments. This review explores multiomics analysis, termed nanomedomics, to uncover how nanomedicines work, aiding future drug development.

Keywords:
drug deliverygenomicsmechanism of actionmetabolomicsmultiomicsnanomedicinenanomedomicsproteomicsregenerative medicinetranscriptomics

More Related Videos

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

10.3K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.5K

Related Experiment Videos

Last Updated: Jun 28, 2025

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

360
Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

10.3K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.5K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Nanomedicines, utilizing diverse nanomaterials, offer enhanced biocompatibility, solubility, and targeting over traditional drugs.
  • Several nanomedicine formulations are approved or in clinical trials, demonstrating significant therapeutic potential.
  • A major hurdle in nanomedicine development is the limited understanding of their molecular mechanisms of action.

Purpose of the Study:

  • To critically review the application of multiomics analysis, termed nanomedomics, for elucidating nanomedicine mechanisms.
  • To discuss the advantages, current applications, and future directions of nanomedomics in nanomedicine research.
  • To highlight how a deeper mechanistic understanding can accelerate nanomedicine development and clinical translation.

Main Methods:

  • Literature review and critical discussion of multiomics strategies applied to nanomedicine.
  • Analysis of existing studies employing techniques like genomics, transcriptomics, proteomics, and metabolomics.
  • Synthesis of information regarding the integration of multiomics data for mechanistic insights.

Main Results:

  • Multiomics analysis provides a comprehensive approach to deciphering the complex molecular interactions of nanomedicines.
  • Nanomedomics can reveal off-target effects, metabolic pathways affected, and cellular responses to nanomedicine interventions.
  • The integration of multiomics data offers a systems-level view of nanomedicine action, surpassing traditional single-target approaches.

Conclusions:

  • Nanomedomics is a powerful strategy to overcome the knowledge gap in nanomedicine mechanisms of action.
  • A thorough understanding of molecular mechanisms facilitated by nanomedomics is crucial for rational nanomedicine design and optimization.
  • This approach holds significant promise for advancing the development and clinical success of novel nanomedicines.