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Systemic immune-inflammation index is associated with cardiac complications following acute ischemic stroke: A

Xiaodi Hao1, Mingfang Zhu1, Zhengyu Sun1

  • 1Department of Neurology, Zhengzhou University People's Hospital, Zhengzhou University, Zhengzhou, Henan 450003, China.

Clinical Neurology and Neurosurgery
|April 18, 2024
PubMed

Insights

The early systemic immune-inflammation (SII) index is higher in patients experiencing stroke-induced heart syndrome. This index independently predicts cardiac complications following acute ischemic stroke.

Area of Science:

  • Cardiology
  • Neurology
  • Immunology

Background:

  • Stroke-induced heart syndrome is a frequent and serious complication of ischemic stroke.
  • It is associated with poor patient prognosis, necessitating further research into its mechanisms.
  • Understanding these mechanisms is crucial for improving clinical decision-making.

Purpose of the Study:

  • To investigate the association between the early systemic immune-inflammation (SII) index and cardiac complications after acute ischemic stroke.
  • To determine if the SII index can predict the development of stroke-heart syndrome.

Main Methods:

  • Prospective collection and retrospective analysis of acute ischemic stroke patients from January 2020 to August 2022.
  • Inclusion criteria: presentation within 24 hours of symptom onset, absence of infection or cancer.
  • Calculation of the SII index [(neutrophils × platelets/lymphocytes)/1000] from admission laboratory data.

Main Results:

  • 121 patients were analyzed; 24 (19.8%) developed cardiac complications within 14 days.
  • Patients with stroke-heart syndrome exhibited significantly higher SII levels (p<.001).
  • The SII index was an independent predictor of stroke-heart syndrome (aOR 5.089, p=.002).

Conclusions:

  • New-onset cardiovascular complications after stroke are common.
  • The early systemic immune-inflammation (SII) index is strongly associated with these complications.
Abstract

Keywords:
Cardiac complicationsNeutrophil-lymphocyte ratioStrokeStroke-heart syndromeSystemic immune-inflammation index

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