Systemic immune-inflammation index is associated with cardiac complications following acute ischemic stroke: A...

Area of Science:

• Cardiology
• Neurology
• Immunology

Background:

• Stroke-induced heart syndrome is a frequent and serious complication of ischemic stroke.
• It is associated with poor patient prognosis, necessitating further research into its mechanisms.
• Understanding these mechanisms is crucial for improving clinical decision-making.

Purpose of the Study:

• To investigate the association between the early systemic immune-inflammation (SII) index and cardiac complications after acute ischemic stroke.
• To determine if the SII index can predict the development of stroke-heart syndrome.

Main Methods:

• Prospective collection and retrospective analysis of acute ischemic stroke patients from January 2020 to August 2022.
• Inclusion criteria: presentation within 24 hours of symptom onset, absence of infection or cancer.
• Calculation of the SII index [(neutrophils × platelets/lymphocytes)/1000] from admission laboratory data.

Main Results:

• 121 patients were analyzed; 24 (19.8%) developed cardiac complications within 14 days.
• Patients with stroke-heart syndrome exhibited significantly higher SII levels (p<.001).
• The SII index was an independent predictor of stroke-heart syndrome (aOR 5.089, p=.002).

Conclusions:

• New-onset cardiovascular complications after stroke are common.
• The early systemic immune-inflammation (SII) index is strongly associated with these complications.