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DNA modifications: Biomarkers for the exposome?

Carolina Möller1, Jazmine Virzi1, Yuan-Jhe Chang2

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Environmental Toxicology and Pharmacology
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The exposome encompasses all life exposures. DNA adductomics comprehensively analyzes DNA modifications, revealing environmental disease origins and enabling exposure source identification.

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Area of Science:

  • Environmental Health Sciences
  • Toxicology
  • Molecular Biology

Background:

  • The exposome comprises all environmental exposures throughout life, influencing health.
  • Environmental exposures can cause DNA modifications linked to diseases like cancer.
  • Traditional methods limited the assessment of multiple DNA modifications simultaneously.

Purpose of the Study:

  • To introduce DNA adductomics as a method for comprehensive DNA modification analysis.
  • To highlight DNA adductomics' potential in understanding the exposome and disease etiology.
  • To demonstrate the utility of adductomics in tracing environmental exposure sources.

Main Methods:

  • Development and application of DNA adductomics to identify and quantify diverse DNA modifications.
  • Utilizing patterns of DNA adducts to infer exposure origins.
  • Integration with other 'omic' approaches for a holistic exposome analysis.

Main Results:

  • DNA adductomics provides a comprehensive profile of DNA adduct burden.
  • Patterns of DNA modifications can be linked to specific environmental exposures.
  • This approach facilitates a 'top-down' investigation of environmental health impacts.

Conclusions:

  • DNA adductomics is a powerful tool for dissecting the exposome.
  • It enables a deeper understanding of the environmental factors contributing to human diseases.
  • This methodology is crucial for identifying exposure sources and mitigating health risks.