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An inulin-based glycovesicle for pathogen-targeted drug delivery to ameliorate salmonellosis

Yujie Xu1, Congmin Niu2, Shuyi Liang2

  • 1College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling 712100, Shaanxi, China.

International Journal of Biological Macromolecules
|April 18, 2024
PubMed

Insights

Novel nanomicelles delivering levofloxacin and inulin show promise for treating inflammatory bowel disease. These targeted micelles combat pathogens and restore gut bacteria, offering a superior therapeutic effect compared to traditional antibiotics.

Area of Science:

  • Gastroenterology
  • Microbiology
  • Nanotechnology

Background:

  • Inflammatory bowel disease (IBD) pathogenesis and remission are linked to gut microbiota composition.
  • Conventional antibiotics can disrupt the gut microbiome, leading to dysbiosis and reduced therapeutic efficacy.
  • Developing targeted therapies is crucial for effective IBD treatment.

Purpose of the Study:

  • To develop novel H2S-responsive nanomicelles coupling inulin with levofloxacin for targeted delivery.
  • To evaluate the efficacy of these nanomicelles in treating salmonellosis and ameliorating inflammation in vivo.
  • To assess the prebiotic effect of inulin on gut microbiota balance.

Main Methods:

  • Synthesis of disulfide-bonded nanomicelles encapsulating inulin and levofloxacin.
  • In vivo evaluation in a mouse model of salmonellosis.
  • Assessment of bacterial load, gut barrier function, and inflammatory markers.

Main Results:

  • The nanomicelles selectively targeted inflamed colonic tissue.
  • Levofloxacin release was rapid and pathogen-specific.
  • Inulin supplementation increased beneficial Bifidobacteria and Lactobacilli.
  • Multifunctional nanomicelles demonstrated superior anti-inflammatory effects compared to free levofloxacin.

Conclusions:

  • Pathogen-targeted glycovesicles are a promising drug delivery platform for IBD treatment.
  • This approach enhances antibacterial efficacy while modulating the gut microbiome.
  • The developed nanomicelles offer a potential strategy to improve IBD management.
Keywords:
H(2)S-responsivenessHomeostasisInflammationInulinNanomicelles

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