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Recurrence of Glandular Odontogenic Cysts: A Systematic Review
Alberto Peraza Labrador1,2, Ashim Shrestha3, Marianela Gonzalez4
1Department of Diagnostic Sciences, Texas A&M University School of Dentistry, 3302 Gaston Avenue, Dallas, TX, 75246, USA. ajpl26@yahoo.com.
Head and Neck Pathology
|April 18, 2024
Summary
Glandular odontogenic cysts (GOCs) show aggressive behavior and high recurrence rates. Treatment type, not specific histologic features, appears to correlate with GOC recurrence, necessitating long-term follow-up.
Area of Science:
- Oral pathology
- Odontogenic tumors
- Surgical oncology
Background:
- Glandular odontogenic cyst (GOC) is a rare benign jaw cyst.
- GOCs exhibit a high rate of recurrence.
Purpose of the Study:
- To systematically review demographic and histologic features of recurrent GOCs.
- To identify factors associated with GOC recurrence.
Main Methods:
- Systematic review of English-language case reports, case series, and retrospective studies (1988-2023).
- Analysis of demographics, symptoms, location, radiographic and histopathologic features, treatment, and follow-up data.
Main Results:
- Eighteen recurrent GOC cases were identified (50% female, 50% male; average age 44.7 years).
- Most common location: anterior mandible (50%). Most patients were asymptomatic (55.6%).
- Key histologic features included mucous cells (88.9%), variable thickness (83.3%), eosinophilic cuboidal cells (88.9%), microcysts (83.3%), and clear cells (77.8%).
Conclusions:
- GOCs demonstrate aggressive behavior.
- Treatment type, not specific histologic features, showed the strongest correlation with recurrence.
- Long-term follow-up (at least 5 years) is recommended due to higher recurrence rates between years 3-5.
