Selective Delivery of Clindamycin Using a Combination of Bacterially Sensitive Microparticle and Separable

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Nurul Fauziah1, Nur Annisa Safirah1, Iis Nurul Rahmadani1

  • 1Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, South Sulawesi, Indonesia.

Pharmaceutical Research
|April 18, 2024
PubMed
Abstract

Insights

This study developed a novel drug delivery system for clindamycin (CLY) to treat diabetic foot infections (DFI). The bacteria-sensitive microparticle patch (MP-CLY-SEMAP) improved drug delivery and reduced bacterial viability.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Dermatology

Background:

  • Diabetic foot infection (DFI) is a common complication of diabetes mellitus.
  • Current treatments with clindamycin (CLY) via oral or intravenous routes cause significant side effects.
  • There is a need for improved localized drug delivery methods for DFI.

Purpose of the Study:

  • To develop and characterize a novel bacteria-sensitive microparticle system (MP-CLY) for clindamycin (CLY) encapsulation.
  • To formulate MP-CLY into a separable effervescent microarray patch (MP-CLY-SEMAP) for enhanced skin penetration and localized delivery.
  • To evaluate the dermatokinetic profile and antibacterial efficacy of the MP-CLY-SEMAP system.

Main Methods:

  • Clindamycin (CLY) was encapsulated into polycaprolactone (PCL) microparticles (MP-CLY).
  • MP-CLY was incorporated into a separable effervescent microarray patch (MP-CLY-SEMAP).
  • Characterization included encapsulation efficiency, in vitro release studies, mechanical properties, and ex vivo dermatokinetic testing on infected skin models.

Main Results:

  • MP-CLY showed high encapsulation of CLY with no chemical structure alteration.
  • In vitro release demonstrated bacteria-triggered and controlled release of CLY.
  • MP-CLY-SEMAP exhibited optimal mechanical properties and efficient skin penetration, leading to a 99.99% reduction in bacterial viability ex vivo.

Conclusions:

  • The MP-CLY-SEMAP system represents a proof-of-concept for improved localized delivery of CLY for DFI.
  • This novel delivery system enhances the dermatokinetic profile of CLY.
  • Further in vivo studies in animal models are warranted to validate the efficacy and safety of MP-CLY-SEMAP.
Keywords:
bacterially sensitive microparticleclindamycindermatokineticdiabetic foot infectionpolycaprolactoneseparable effervescent microarray patch

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