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Typhlitis in adults.

A J Taylor, W J Dodds, J E Gonyo

    Gastrointestinal Radiology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Typhlitis, or neutropenic enterocolitis, is a serious intestinal condition affecting adults with blood cancers. Early diagnosis and treatment are crucial, but the short-term outlook for typhlitis remains poor.

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    Area of Science:

    • Gastroenterology
    • Hematology
    • Oncology

    Background:

    • Typhlitis, initially described in children, is a significant clinical entity also observed in adults, particularly those with hematologic malignancy or aplastic anemia.
    • This condition involves a necrotizing process affecting the right colon and potentially other intestinal areas.
    • It is often characterized by secondary bacterial colonization of mucosal ulcers, leading to sepsis and fever.

    Observation:

    • This study describes 6 adult patients diagnosed with typhlitis.
    • The review examines the key clinical and radiographic features associated with typhlitis.
    • A high index of suspicion combined with specific clinical and radiographic findings can facilitate an accurate presumptive diagnosis.

    Findings:

    • Typhlitis presents with a range of clinical and radiographic manifestations.

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  • The multifactorial necrotizing process primarily affects the right colon.
  • Septicemia and pyrexia are common complications due to bacterial colonization of ulcers.

    • Implications:

    • Accurate presumptive diagnosis of typhlitis is possible with heightened clinical awareness and characteristic findings.
    • Prompt institution of appropriate therapy is essential for managing typhlitis.
    • Despite therapeutic efforts, the short-term prognosis for typhlitis in adults remains guarded.