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Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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Related Experiment Video

Updated: Jun 28, 2025

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

Single-cell immune repertoire analysis.

Sergio E Irac¹, Megan Sioe Fei Soon², Nicholas Borcherding^3,4

¹Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

|April 18, 2024

Summary

This summary is machine-generated.

Analyzing single-cell T cell and B cell antigen receptor sequencing data offers deep insights into adaptive immunity. This review highlights computational advances overcoming challenges in interpreting complex immune receptor repertoire data.

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Last Updated: Jun 28, 2025

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

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Published on: January 12, 2021

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

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Published on: March 15, 2019

Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations

Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations

Published on: August 22, 2019

Area of Science:

Immunology
Computational Biology
Bioinformatics

Background:

Single-cell antigen receptor sequencing provides detailed insights into adaptive immune cells.
Analyzing T cell and B cell receptor repertoires is complex due to data and biological intricacies.
Understanding immune cell development and disease progression relies on this analysis.

Purpose of the Study:

To review computational breakthroughs in single-cell T cell and B cell antigen receptor sequencing data analysis.
To address the challenges in interpreting adaptive immune receptor repertoires.
To highlight advancements transforming the field.

Main Methods:

Review of computational methodologies for single-cell immune repertoire analysis.
Discussion of algorithms and software for processing complex sequencing data.
Synthesis of current computational approaches in the field.

Main Results:

Identification of key computational strategies enhancing single-cell immune repertoire analysis.
Demonstration of how computational advances simplify the interpretation of complex biological data.
Highlighting the transformative impact of these methods on immunological research.

Conclusions:

Computational breakthroughs are essential for unlocking the potential of single-cell antigen receptor sequencing.
Advanced analysis methods enable deeper understanding of adaptive immunity, disease, and therapy.
The field has seen significant progress in analyzing complex immune cell data.