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Updated: Jun 28, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
Recognizing Complexity of CD8 T Cells in Transplantation
Michael Nicosia1, Anna Valujskikh
1Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Abstract:
The major role of CD8 + T cells in clinical and experimental transplantation is well documented and acknowledged. Nevertheless, the precise impact of CD8 + T cells on graft tissue injury is not completely understood, thus impeding the development of specific treatment strategies. The goal of this overview is to consider the biology and functions of CD8 + T cells in the context of experimental and clinical allotransplantation, with special emphasis on how this cell subset is affected by currently available and emerging therapies.
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