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Epigenetic age oscillates during the day.

Karolis Koncevičius1, Akhil Nair1,2, Aušrinė Šveikauskaitė1

  • 1Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.

Aging Cell
|April 19, 2024
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Summary

Epigenetic clocks, used in aging research, show a 24-hour cycle. This circadian rhythm affects age predictions, highlighting the importance of sample collection time for accurate epigenetic age estimation.

Keywords:
DNA modificationWBC subtype heterogeneitycircadian rhythmsepigenetic ageepigenetic clocks

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Area of Science:

  • Chronobiology
  • Epigenetics
  • Aging Research

Background:

  • Epigenetic clocks are widely used biomarkers for aging and disease.
  • Previous studies have not extensively investigated the temporal dynamics of epigenetic age predictions.

Purpose of the Study:

  • To investigate the 24-hour periodicity of epigenetic age predictions.
  • To assess the impact of circadian rhythms on epigenetic clock accuracy.

Main Methods:

  • Utilized 17 different epigenetic clocks with blood samples collected across a 24-hour period.
  • Analyzed oscillations in epigenetic age estimates.
  • Examined purified neutrophil fractions to explore intracellular contributions.

Main Results:

  • Thirteen out of 17 epigenetic clocks exhibited significant 24-hour oscillations.
  • Youngest and oldest age estimates occurred around midnight and noon, respectively.
  • Circadian variations were observed even in purified neutrophils, suggesting intracellular epigenomic oscillations.

Conclusions:

  • Epigenetic age predictions display a consistent 24-hour periodicity.
  • Circadian variations in epigenetic clocks, potentially due to cell composition and intracellular factors, impact age estimation.
  • Time-of-day is a critical factor for accurate epigenetic age assessment.