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Updated: Jun 28, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Organocatalyst-mediated asymmetric one-pot/two domino/three-component coupling reactions for the synthesis of
Naoki Mori1, Toshiki Tachibana1, Nariyoshi Umekubo1
1Department of Chemistry, Graduate School of Science, Tohoku University Sendai 980-8578 Japan yujiro.hayashi.b7@tohoku.ac.jp.
Abstract:
Highly substituted trans-hydrindanes were synthesized by the three-component coupling reactions of 1,3-diethyl 2-(2-oxopropylidene)propanedioate and two different α,β-unsaturated aldehydes catalyzed by diphenylprolinol silyl ether. The reaction proceeds via two successive independent catalytic domino reactions in a one-pot reaction by a single chiral catalyst. Domino reactions involve Michael/Michael and Michael/aldol reactions to afford trans-hydrindanes with excellent diastereoselectivity and nearly optically pure form.
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