Related Experiment Video

Updated: Apr 30, 2026

Measuring Bacterial Load and Immune Responses in Mice Infected with Listeria monocytogenes
12:50

Measuring Bacterial Load and Immune Responses in Mice Infected with Listeria monocytogenes

Published on: August 9, 2011

31.2K

Impaired meningeal lymphatic drainage in Listeria monocytogenes infection

Jian Feng1, Yuanzhen Ren1, Xilin Wang1,2

  • 1Shanghai Engineering Research Center of Organ Repair, School of Life Sciences, Shanghai University, Shanghai, China.

Frontiers in Immunology
|April 19, 2024
PubMed

Insights

Listeria monocytogenes infection causes new lymphatic vessel growth and impairs drainage in mice. This bacterial infection may disrupt lymphatic vessel development, worsening brain inflammation and bacterial load.

Area of Science:

  • Immunology
  • Vascular Biology
  • Microbiology

Background:

  • Lymphatic vessels play a role in disease, including bacterial infections.
  • Listeria monocytogenes (LM) infection is a severe bacterial infection affecting multiple organs.

Purpose of the Study:

  • To investigate the impact of LM infection on lymphatic vessel morphology and function.
  • To explore the role of meningeal lymphatic vessels (MLVs) in LM infection.

Main Methods:

  • Induction of LM infection in mice.
  • Analysis of meningeal and mesenteric lymphangiogenesis.
  • Assessment of MLVs-mediated macromolecule drainage.
  • Gene expression analysis (Gata2, Foxc2).
  • Photodynamic ablation of MLVs.

Main Results:

  • LM infection induced lymphangiogenesis in meningeal and mesenteric lymphatic vessels.
  • Impaired drainage of macromolecules via MLVs.
  • Downregulation of lymphatic vessel development genes (Gata2, Foxc2).
  • Photodynamic ablation of MLVs worsened brain inflammation and bacterial load.

Conclusions:

  • LM infection induces lymphangiogenesis and impairs MLVs drainage.
  • LM infection may affect lymphatic vessel development, including cell polarization and valve formation.
  • MLVs play a protective role in LM brain infection, and their ablation exacerbates disease.
Keywords:
Listeria monocytogeneslymphatic drainagelymphatic expansionmeningeal lymphatic vesselsmesenteric lymphatic vessels

More Related Videos

Listeria monocytogenes Infection of the Brain05:02

Listeria monocytogenes Infection of the Brain

Published on: October 2, 2018

12.7K
Induction of Leptomeningeal Cells Modification Via Intracisternal Injection05:55

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Published on: May 7, 2020

8.1K

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
15
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
24
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
22
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
21