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Periprocedural Bridging Therapy in Patients With Mechanical Heart Valves
Nivedha Balaji1, Oluwafemi Olukayode1, Fardeen Faiz2
1Internal Medicine, Northeast Georgia Medical Center Gainesville, Gainesville, USA.
Cureus
|April 19, 2024
Summary
Mechanical heart valves (MHVs) require anticoagulation. Bridging therapy with enoxaparin, a low-molecular-weight heparin, did not prevent an acute thrombus in a patient with MHVs, highlighting a gap in current guidelines.
Area of Science:
- Cardiology
- Pharmacology
- Thrombosis Research
Background:
- Mechanical heart valves (MHVs) are prone to thrombosis, necessitating lifelong anticoagulation with vitamin K antagonists (VKAs).
- Periprocedural bridging anticoagulation, using unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH), is common practice to mitigate thromboembolic risks.
- Current clinical guidelines lack definitive recommendations for optimal anticoagulation management in patients with MHVs.
Keywords:
bridging anticoagulationlow-molecular-weight heparinmechanical heart valvesthrombusunfractionated heparinMore Related Videos
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