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Updated: May 6, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Impact of Vaccination Status on Outcome of Patients With COVID-19 and Acute Ischemic Stroke Undergoing Mechanical
Cornelius Deuschl1, Lukas Goertz2, Christoph Kabbasch2
1Institute for Diagnostic and Interventional Radiology and Neuroradiology University Hospital Essen Essen Germany.
Journal of the American Heart Association
|April 19, 2024
Summary
COVID-19 vaccination did not impact outcomes for patients with acute ischemic stroke undergoing mechanical thrombectomy. However, acute COVID-19 infection worsened outcomes in these patients.
Area of Science:
- Neurology
- Infectious Diseases
- Cardiovascular Medicine
Background:
- Limited data exists on COVID-19 vaccination impact in acute ischemic stroke patients undergoing mechanical thrombectomy.
- This multicenter study addresses the scarcity of information on this patient population.
Purpose of the Study:
- To evaluate the impact of COVID-19 vaccination on clinical and angiographic outcomes in patients with acute ischemic stroke undergoing mechanical thrombectomy.
- To determine if COVID-19 vaccination influences outcomes in patients with COVID-19 and acute ischemic stroke.
Main Methods:
- Retrospective analysis of 137 patients (48 vaccinated, 89 unvaccinated) with COVID-19 and acute ischemic stroke treated with mechanical thrombectomy across 20 centers (Jan 2020-Jan 2023).
- Assessment of baseline demographics, angiographic outcomes (modified Thrombolysis in Cerebral Infarction score), and clinical outcomes (modified Rankin Scale score at discharge).
- Multivariate analysis to identify predictors of unfavorable outcomes (modified Rankin Scale score >3).
Main Results:
- Angiographic outcomes were similar between vaccinated and unvaccinated groups (mRs ≥2b: 85.4% vs. 86.5%, P=0.859).
- Functional independence (mRs ≤2) rates were comparable (23.3% vs. 20.9%, P=0.763), with identical mortality rates (30%).
- Vaccination status was not a significant predictor of unfavorable outcomes (P=0.957), but acute COVID-19 infection remained significant (OR, 1.197; P=0.041).
Conclusions:
- COVID-19 vaccination showed no significant impact on angiographic or clinical outcomes in patients with acute ischemic stroke and COVID-19 undergoing mechanical thrombectomy.
- Worsening of outcomes was confirmed to be attributable to acute COVID-19 infection itself.
- Findings suggest focusing on managing acute COVID-19 infection in stroke patients rather than vaccination status for outcome prediction.
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