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Updated: Jun 28, 2025

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
Published on: April 10, 2012
Heparan sulfates and heparan sulfate proteoglycans in hematopoiesis
Richard T Piszczatowski1,2, Hannes E Bülow3,4,5, Ulrich Steidl1,5,6,7,8
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY.
Abstract:
From signaling mediators in stem cells to markers of differentiation and lineage commitment to facilitators for the entry of viruses, such as HIV-1, cell surface heparan sulfate (HS) glycans with distinct modification patterns play important roles in hematopoietic biology. In this review, we provide an overview of the importance of HS and the proteoglycans (HSPGs) to which they are attached within the major cellular subtypes of the hematopoietic system. We summarize the roles of HSPGs, HS, and HS modifications within each main hematopoietic cell lineage of both myeloid and lymphoid arms. Lastly, we discuss the biological advances in the detection of HS modifications and their potential to further discriminate cell types within hematopoietic tissue.
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