[Effect of chromosomal polymorphisms on reproductive outcomes of in vitro fertilization-embryo transfer]

To explore the effect of chromosomal polymorphic variations on the outcome of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) treatment for infertile couples. Methods： In this retrospective study, 418 infertile couples, who received their first IVF/ICSI-ET treatment cycles in Reproductive Medicine Center of Xi'an People's Hospital (Xi'an Fourth Hospital) from Jan. 2021to Jan. 2023, were included and divided into two groups: group A (the infertile couples with normal chromosome) and group B(with chromosomal polymorphic variations); The group B divided into 2 groups, group C(male carrier, n= 44), group D (female carrier, n= 37). The No. of oocyte, 2PN fertilization rate, fertilization rate,multi-PN fertilization rate, quality embryo rate, cleavage rate, normal cleavage rate, blastocyst formation rate,clinical pregnancy rate after IVF/ICSI-ET treatment were compared and analyzed. Logistic regression analysis was performed to study the relationship between clinical pregnancy rate and chromosome variation. Results： A total of 418 infertile couples received IVF/ICSI-ET treatment were enrolled, with 81 in the chromosomal polymorphic group (group A), and 337 in the normal chromosomal group (group B). The quality embryo rate were signifcantly higher in the group A（59.21% vs 52.42%,P<0.05）,the other outcomes have no significant differences between the two groups ( P>0.05). The No. of oocyte, 2PN fertilization rate, fertilization rate,multi-PN fertilization rate, quality embryo rate, cleavage rate, normal cleavage rate, blastocyst formation rate showed no signifcantdiferences among group A, group C and group D (P>0.05). The clinical pregnancy rate in group A is higer than group C and group D (56.7% vs 52.3% vs 40.5%), But there were no signifcantly diferent among the three groups (P>0.05). Logistic regression analysis indicated that the Chromosomal polymorphisms were not associated with clinical pregnancy rate (P>0.05).Conclusion： Chromosomal polymorphisms appear to have no significant effect on the outcome of IVF/ICSI-ET treatment for infertile couples.