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Updated: Jun 28, 2025
13:19
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
16.6K
[Research progress on markers related to angiogenesis and stemness characteristics in prostate cancer]
1Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China .
Zhonghua Nan Ke Xue = National Journal of Andrology
|April 19, 2024
Summary
Prostate cancer (PCa) recurrence, metastasis, and drug resistance are linked to tumor angiogenesis and cancer stemness. This review explores how these factors create a harmful cycle driving PCa progression and mortality.
Area of Science:
- Oncology
- Cancer Biology
- Urology
Context:
- Prostate cancer (PCa) remains a significant cause of cancer mortality.
- Tumor angiogenesis and cancer stemness are critical hallmarks of advanced PCa.
- A complex interplay exists between the tumor microenvironment, angiogenesis, and cancer stem cells.
Purpose:
- To summarize regulatory factors of tumor angiogenesis in PCa.
- To explore the role of cancer stemness characteristics in PCa development.
- To elucidate the synergistic relationship between angiogenesis and stemness in promoting PCa progression.
Summary:
- Cancer stem cells promote tumor angiogenesis, creating a vascularized microenvironment.
- This microenvironment, in turn, supports cancer stem cell growth, forming a vicious cycle.
- This cycle is a key driver of PCa recurrence, metastasis, and therapeutic resistance.
Impact:
- Provides a comprehensive overview of key factors driving lethal prostate cancer.
- Highlights the interconnectedness of tumor angiogenesis and cancer stemness.
- Offers insights into potential therapeutic targets for overcoming treatment resistance in PCa.
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