High keratin 15 expression reflects favorable prognosis in early cervical cancer patients
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View abstract on PubMed
Summary
This summary is machine-generated.High Keratin 15 (KRT15) expression in early cervical cancer indicates better tumor differentiation and larger tumor size. This finding suggests KRT15 may serve as a positive prognostic marker for disease-free survival in these patients.
Area Of Science
- Oncology
- Cancer Biomarkers
- Gynecologic Oncology
Background
- Keratin 15 (KRT15) has shown variable prognostic significance across different cancer types.
- The prognostic role of KRT15 in early cervical cancer patients undergoing tumor resection is not well-established.
Purpose Of The Study
- To investigate the association between KRT15 expression levels and patient prognosis in early cervical cancer.
- To determine if KRT15 can serve as a predictive biomarker for survival outcomes in this patient cohort.
Main Methods
- Retrospective analysis of 147 early cervical cancer patients who underwent tumor resection.
- Immunohistochemistry (IHC) was used to detect KRT15 expression in tumor tissues.
- KRT15 IHC scores were calculated based on staining intensity and percentage of positive cells.
Main Results
- Elevated KRT15 IHC scores correlated with moderate to well-differentiated tumors, smaller tumor size (≤4 cm), and early FIGO stages (Ia/Ib).
- High KRT15 expression was linked to longer disease-free survival (DFS) and overall survival (OS), and independently predicted increased DFS.
- KRT15 expression was a favorable prognostic factor in specific subgroups, including HPV-positive patients and those not receiving adjuvant therapy.
Conclusions
- High KRT15 expression is associated with favorable clinicopathological features in early cervical cancer.
- KRT15 expression serves as a positive prognostic indicator for improved survival, particularly disease-free survival, in patients undergoing tumor resection.
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