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Related Concept Videos

Inhaled Medications01:23

Inhaled Medications

256
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
256
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

338
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

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Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
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Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

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Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
214
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

274
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
274
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

428
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Intratracheal Administration of Dry Powder Formulation in Mice
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Liposomes for Inhalation.

Hui Xin Ong1, Daniela Traini1, Paul M Young2

  • 1Woolcock Institute for Medical Research, University of Sydney, Sydney, NSW, Australia.

Journal of Aerosol Medicine and Pulmonary Drug Delivery
|April 19, 2024
PubMed
Summary
This summary is machine-generated.

Liposomes, biocompatible drug carriers, offer versatile pulmonary delivery for lung diseases like cancer and infections. Their tunable properties enhance drug efficacy and reduce toxicity for targeted lung therapies.

Keywords:
antibioticscontrolled releaseinhalationliposomesrespiratory disease

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Area of Science:

  • Pulmonary Medicine
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Liposomes formulated with lung-like phospholipids offer biocompatibility for pulmonary applications.
  • Their versatile nature allows for tailored design to meet specific delivery needs.
  • Liposomes are utilized in treating lung cancer, cystic fibrosis, and infections.

Purpose of the Study:

  • To provide an overview of liposomal formulation and delivery strategies for lung diseases.
  • To highlight the benefits of liposomes in pulmonary medicine.
  • To discuss the application of liposomes in treating various lung conditions.

Main Methods:

  • Overview of liposomal formulation techniques.
  • Discussion of physicochemical property manipulation for targeted delivery.
  • Review of delivery and release mechanisms for pulmonary administration.

Main Results:

  • Liposomes demonstrate improved pharmacokinetics and reduced toxicity.
  • Enhanced therapeutic efficacy and delivery of poorly soluble drugs are achieved.
  • Benefits include taste masking, protection from degradation, and targeted cellular therapy.

Conclusions:

  • Liposomes represent a versatile and effective drug delivery system for pulmonary medicine.
  • Tailoring liposomal properties enables innovative treatments for diverse lung diseases.
  • This approach holds significant promise for improving patient outcomes in lung conditions.