Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhaled Medications01:23

Inhaled Medications

256
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
256
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

338
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
338
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

133
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
133
Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

2.8K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.8K
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

428
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
428

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of atmospheric electrical charges on ryegrass pollen rupture and sub-pollen particle release.

Scientific reports·2026
Same author

Impact of Atmospheric Charge Regimes (Static Fields and Arcing) on Airborne Tree Pollen Rupture under Dry and Wet Conditions.

Environmental science & technology·2026
Same author

Protein papers from microfibrillated silk for biomedical membrane applications.

Colloids and surfaces. B, Biointerfaces·2025
Same author

Fork to farm: reverse engineering a food system.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2025
Same author

Scale resolving simulations of the effect of glottis motion and the laryngeal jet on flow dynamics during respiration.

Computer methods and programs in biomedicine·2024
Same author

The perfect storm: temporal analysis of air during the world's most deadly epidemic thunderstorm asthma (ETSA) event in Melbourne.

Therapeutic advances in respiratory disease·2023
Same journal

Safety and Pharmacokinetic Data for Inhaled Administration of Nintedanib Dry Powder Inhalation for Treatment of Pulmonary Fibrotic Diseases.

Journal of aerosol medicine and pulmonary drug delivery·2026
Same journal

Selecting the Optimal Inhaler in Asthma: Respiratory and Peripheral Muscle Strength as Predictors of DPI and MDI Response.

Journal of aerosol medicine and pulmonary drug delivery·2026
Same journal

Usability of Levodopa Cyclops<sup>®</sup> Compared to INBRIJA<sup>®</sup> During an off Episode in Parkinson's Disease Patients.

Journal of aerosol medicine and pulmonary drug delivery·2026
Same journal

Design of Dry Powder Inhalers: 1. Does Size Matter?

Journal of aerosol medicine and pulmonary drug delivery·2026
Same journal

Design of Dry Powder Inhalers: 2. The Impact of Suboptimal Peak Inspiratory Flow Rates on Bronchodilation in Patients with Obstructive Lung Diseases.

Journal of aerosol medicine and pulmonary drug delivery·2026
Same journal

Inhaler Adherence and Treatment Behaviors in COPD: A Study from Both Sides of the Aegean Sea.

Journal of aerosol medicine and pulmonary drug delivery·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2025

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

7.7K

Developing Dry Powder Inhaler Formulations.

David A V Morton1, David Barling2

  • 1School of Engineering, Faculty of Science, Engineering and Built Environment, Deakin University, Waurn Ponds, VIC, Australia.

Journal of Aerosol Medicine and Pulmonary Drug Delivery
|April 19, 2024
PubMed
Summary
This summary is machine-generated.

Designing effective dry powder inhaler (DPI) formulations is complex due to cohesive powder systems. Successful development requires multidisciplinary teams addressing formulation, device, and patient handling for optimal drug delivery.

Keywords:
aerosolizationaerosolsdry powder inhalersfluidizationmicronizationparticle engineeringpowder formulationpowder surface modification

More Related Videos

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

845
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.7K

Related Experiment Videos

Last Updated: Jun 28, 2025

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

7.7K
Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

845
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.7K

Area of Science:

  • Pharmaceutical Sciences
  • Inhalation Technology
  • Materials Science

Background:

  • Dry powder inhalers (DPIs) dominate the inhaled product market by sales value.
  • Despite market leadership, fundamental understanding and first-principles design of DPIs remain challenging.
  • The complexity of fine cohesive powder systems underlies these difficulties.

Purpose of the Study:

  • To provide a contemporary technical perspective on dry powder inhaler (DPI) formulations.
  • To highlight the scientific challenges and complexities in designing DPIs.
  • To review formulation types, particle engineering, and performance factors.

Main Methods:

  • Review of existing literature and technical perspectives on DPI formulations.
  • Description of various DPI formulation types and their evolution.
  • Analysis of particle engineering processes for micron-sized drug particles.
  • Discussion of carrier-based and carrier-free compositions.
  • Examination of material, bulk, and interfacial properties influencing performance.

Main Results:

  • DPI formulation development is challenging due to the inherent complexity of cohesive powders.
  • Successful product development necessitates a coordinated team approach, integrating device, formulation, and patient factors.
  • Various formulation strategies and particle engineering techniques exist to aerosolize fine drug particles.
  • Formulation performance is critically dependent on material properties and drug-delivery characteristics.

Conclusions:

  • Underestimating the difficulty of DPI product development is a common pitfall.
  • A holistic approach considering device, formulation, and patient handling is crucial for success.
  • Future DPI market choices will balance technological advancements with affordability.