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The Micturition Reflex01:26

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Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
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Aged and Young Adult Rats Respond Similarly to Highly Selective Neurokinin 2 Receptor Agonists That Produce Urination and Defecation Without Producing Cardiovascular Side Effects.

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Recent Developments in On-Demand Voiding Therapies.

Karl B Thor1, Lesley Marson2, Mary A Katofiasc2

  • 1Dignify Therapeutics, LLC, Durham, North Carolina kthor@dignifytherapeutics.com.

The Journal of Pharmacology and Experimental Therapeutics
|April 19, 2024
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Summary
This summary is machine-generated.

New drug therapies offer on-demand bladder and bowel control for individuals with neurologic injuries. These treatments aim to reduce reliance on catheters and manual bowel programs, improving quality of life.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Urology
  • Gastroenterology

Background:

  • Neurologic injuries and diseases impair voluntary bladder and bowel control.
  • Current management involves catheters and manual bowel programs, which are burdensome and have complications.
  • Restoring bladder and bowel function is a high priority for patients with spinal cord injury.

Purpose of the Study:

  • To discuss novel drug candidates for on-demand voiding therapies.
  • To address the unmet medical need for rapid-onset, short-duration voiding treatments.
  • To review emerging therapies for bladder and bowel dysfunction.

Main Methods:

  • Discussion of two drug candidates: [Lys3,Gly8,-R-γ-lactam-Leu9]-NKA(3-10) (DTI-117) and capsaicin (DTI-301).
  • Review of clinical studies for combination drug therapy via iontophoresis.
  • Examination of preclinical studies for neuromodulation devices.

Main Results:

  • DTI-117, a neurokinin2 receptor agonist, induces urination and defecation systemically.
  • Capsaicin (DTI-301), a TRPV1 receptor agonist, induces defecation intrarectally.
  • Emerging therapies show promise for inducing urination and defecation.

Conclusions:

  • On-demand, drug-induced voiding therapies could significantly reduce the need for invasive management.
  • These therapies have the potential to decrease healthcare costs and improve patient quality of life.
  • Restoring bladder and bowel control is crucial for individuals with neurologic impairments.