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Updated: Jun 28, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

958

Circ_0087851 suppresses colorectal cancer malignant progression through triggering miR-593-3p/BAP1-mediated

Ming Huang1, Ting Gao1, Xianyong Chen1

  • 1Department of Pathology, Affiliated Hospital of Xiangnan University, Chenzhou, 423000, Hunan, China.

Journal of Cancer Research and Clinical Oncology
|April 20, 2024
PubMed
Abstract

Insights

Circular RNAs (circRNAs) regulate colorectal cancer (CRC) progression. This study found circ_0087851 suppresses CRC by promoting ferroptosis via the miR-593-3p/BAP1 pathway, offering a potential therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are crucial regulators in tumorigenesis, including colorectal cancer (CRC).
  • Ferroptosis, a distinct form of cell death, plays a role in tumor malignancy.
  • Understanding circRNA functions in CRC and ferroptosis is vital for therapeutic development.

Purpose of the Study:

  • To investigate the role of circ_0087851 in colorectal cancer progression.
  • To explore the impact of circ_0087851 on ferroptosis in CRC.
  • To elucidate the molecular mechanism underlying circ_0087851's function in CRC.

Main Methods:

  • Quantitative real-time PCR (qRT-PCR) to assess circ_0087851 expression.
  • In vitro assays (CCK-8, colony formation, Transwell) and in vivo xenograft models to evaluate CRC cell behavior and tumor growth.
  • Biochemical assays to measure ferroptosis markers (iron, Fe2+, lipid ROS).
  • Bioinformatics, luciferase reporter, and RNA pulldown assays to identify molecular interactions.

Main Results:

  • Circ_0087851 expression was significantly reduced in CRC tissues and cells.
  • Overexpression of circ_0087851 inhibited CRC cell proliferation, migration, invasion, and induced ferroptosis in vitro.
  • Upregulation of circ_0087851 suppressed tumor growth in vivo.
  • Circ_0087851 acts as a molecular sponge for miR-593-3p, which targets BAP1, revealing the circ_0087851/miR-593-3p/BAP1 axis.

Conclusions:

  • Circ_0087851 functions as a tumor suppressor and ferroptosis promoter in CRC.
  • The miR-593-3p/BAP1 axis mediates the tumor-suppressive effects of circ_0087851.
  • Circ_0087851 represents a promising biomarker and therapeutic target for colorectal cancer management.
Keywords:
BAP1Circ_0087851Colorectal cancerFerroptosisMiR-593-3p

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