Initial experience with a novel stent-based mechanical thrombectomy device for management of acute myocardial...

Area of Science:

• Cardiology
• Interventional Cardiology
• Medical Devices

Background:

• Acute myocardial infarction (AMI) with large thrombus burden (LTB) presents significant clinical challenges.
• Aspiration thrombectomy is often insufficient for LTB cases.
• Mechanical thrombectomy devices (MTDs) offer a new therapeutic option for coronary thrombotic lesions.

Purpose of the Study:

• To evaluate the early real-world experience with a novel mechanical thrombectomy device (NeVa™ MTD).
• To assess the safety and efficacy of the NeVa™ MTD in patients with AMI and LTB.

Main Methods:

• Analysis of consecutive patients from the prospective OPTIMISER registry (NCT04988672).
• Patients were treated with the NeVa™ MTD for AMI with LTB at a tertiary cardiology facility.
• Outcomes included periprocedural complications, target lesion failure (TLF), target lesion revascularization (TLR), and target vessel myocardial infarction (TV-MI).

Main Results:

• Successful thrombectomy was achieved in 14 out of 15 patients (93%).
• Final TIMI 3 flow was obtained in 87% of patients; no major periprocedural complications occurred.
• One patient (7%) experienced TLR due to stent thrombosis at 10 months post-procedure.

Conclusions:

• The novel NeVa™ MTD appears to be an efficient and safe option for AMI patients with LTB.
• Further randomized trials are necessary to confirm the benefits of the NeVa™ device on procedural and clinical outcomes.