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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Related Experiment Video

Updated: Jun 28, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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Systemic lupus erythematosus.

Alberta Hoi1, Talia Igel1, Chi Chiu Mok2

  • 1Department of Rheumatology, Monash Health, School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.

Lancet (London, England)
|April 20, 2024
PubMed
Summary

Systemic lupus erythematosus (SLE) is a complex autoimmune disease requiring early diagnosis and tailored management. This review covers diagnostic criteria, lifestyle interventions, and modern treatments to achieve remission and manage comorbidities.

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Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease with significant morbidity and mortality.
  • Despite advances, the disease burden remains high, necessitating improved diagnostic and management strategies.
  • Early recognition of characteristic symptoms is crucial for timely diagnosis and intervention.

Purpose of the Study:

  • To outline a systematic diagnostic approach for SLE based on current classification criteria.
  • To discuss non-pharmacological and pharmacological management strategies, including recent therapeutic breakthroughs.
  • To emphasize the importance of achieving remission and managing treatment-related comorbidities.

Main Methods:

  • Review of clinical manifestations, constitutional, mucocutaneous, and musculoskeletal symptoms.
  • Evaluation of diagnostic criteria incorporating clinical domains and autoantibody profiles (e.g., anti-dsDNA, anti-Sm).
  • Discussion of pharmacotherapy (hydroxychloroquine, immunosuppressants) and novel treatments (belimumab, anifrolumab, voclosporin).

Main Results:

  • The latest criteria systematically evaluate weighted clinical manifestations and autoantibody profiles for diagnosis.
  • Lifestyle interventions and patient education enhance quality of life and medication adherence.
  • New treatments offer improved outcomes, but disease variability and access remain challenges.

Conclusions:

  • Achieving remission or low disease activity is the primary treatment goal in SLE.
  • Vigilant management of comorbidities, such as infections and cardiovascular disease, is essential.
  • Tailoring treatment to balance efficacy and treatment-related comorbidities is a priority in SLE care.