Related Experiment Video
Updated: Jun 28, 2025

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
Published on: September 20, 2020
Impact of Short-Term Computerized Cognitive Training on Cognition in Older Adults With and Without Genetic Risk of
Anne Corbett1, Gareth Williams2, Byron Creese3
1Department of Health and Community Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK.
Objectives:
To establish the impact of a 3-minute computerized cognitive training program (START) on cognition in older adults with and without genetic risk of Alzheimer's disease.
Design:
Two-arm randomized controlled trial of the START program.
Setting And Participants:
Remote online trial in adults older than 50 taking part from home.
Methods:
The trial compared the START program with placebo in 6544 people older than 50. Primary outcome was executive function measured through Trailmaking B, with other secondary cognitive measures. Genetic risk profile and ApoE4 status were determined by Illumina Array.
Results:
START conferred benefit to executive function, attention, memory, and a composite measure, including in people with the ApoE4 genotype.
Conclusions And Implications:
The 3-minute START task offers a means of supporting cognitive health in older adults and could be used at scale and within a precision medicine approach to reduce risk of cognitive decline in a targeted way.
More Related Videos
07:31A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills
Published on: February 13, 2020
06:58Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
Published on: January 24, 2020
Related Concept Videos
Cognitive Development During Adulthood
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Alzheimer's Disease: Treatment