68Ga-FAPI-04 positron emission tomography/CT and laparoscopy for the diagnosis of occult peritoneal metastasis in newly diagnosed locally advanced gastric cancer: study protocol of a single-centre prospective cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.This study evaluates 68Ga-FAPI-04 PET/CT for detecting peritoneal metastasis in gastric cancer, aiming to improve treatment decisions by offering a non-invasive alternative to laparoscopy.
Area Of Science
- Oncology
- Nuclear Medicine
- Diagnostic Imaging
Background
- Accurate clinical staging is crucial for gastric cancer treatment decisions.
- Peritoneal metastasis (PM) is the most common gastric cancer metastasis, typically diagnosed via invasive laparoscopy.
- There is an urgent need for safe, non-invasive imaging methods to detect PM.
Purpose Of The Study
- To evaluate the impact of 68Ga-FAPI-04 positron emission tomography/CT (PET/CT) on treatment strategy changes in gastric cancer patients.
- To assess the diagnostic accuracy of 68Ga-FAPI-04 PET/CT in detecting occult peritoneal metastasis compared to laparoscopic exploration.
Main Methods
- A prospective diagnostic accuracy study involving 48 patients with locally advanced gastric or gastro-oesophageal junction adenocarcinoma.
- All participants underwent 68Ga-FAPI-04 PET/CT prior to laparoscopic exploration.
- Primary outcome: proportion of patients with PM detected by 68Ga-FAPI-04 PET/CT leading to therapy change. Secondary outcomes: diagnostic performance metrics (sensitivity, specificity, etc.).
Main Results
- The study is designed to determine the proportion of patients whose treatment strategy is altered based on 68Ga-FAPI-04 PET/CT findings.
- Diagnostic performance of 68Ga-FAPI-04 PET/CT for occult peritoneal metastasis will be analyzed.
Conclusions
- 68Ga-FAPI-04 PET/CT shows potential as a non-invasive tool for staging gastric cancer patients with suspected peritoneal metastasis.
- This functional imaging method may help optimize treatment strategies and avoid unnecessary invasive procedures.
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