Prognostic value of combined psoas muscle mass and controlling nutritional status in patients with pancreatic ductal...

Area of Science:

• Oncology
• Surgical Oncology
• Nutritional Science

Background:

• Pancreatic ductal carcinoma (PDAC) presents a poor prognosis despite advances in multidisciplinary treatment.
• Supportive therapies, including nutritional and perioperative rehabilitation, are not well-established for PDAC patients.
• Assessing patient condition through objective markers is crucial for improving outcomes.

Purpose of the Study:

• To investigate the prognostic value of a combined index using psoas muscle mass index (PMI) and controlling nutritional status (CONUT) score in PDAC patients.
• To determine the relationship between this combined index and overall survival (OS) after radical surgery.

Main Methods:

• A cohort of 101 PDAC patients undergoing radical pancreatectomy was analyzed.
• Patients were stratified into high/low PMI groups and normal/malnutrition groups based on CONUT score.
• A combined 'general condition' grouping (good, moderate, poor) was established to assess prognostic impact on OS.

Main Results:

• The 'poor general condition' group (low PMI and malnutrition) showed a higher proportion of elderly patients (>70 years).
• This group experienced significantly worse prognosis and lower 5-year survival rates (10.9%) compared to moderate (22.3%) and good (36.1%) groups.
• Low PMI and malnutrition status together were identified as an independent poor prognostic factor for postoperative OS.

Conclusions:

• The combined assessment of PMI and CONUT score offers a valuable tool for predicting PDAC prognosis.
• This combined index can aid in identifying patients at higher risk for adverse outcomes after surgery.
• Integrating nutritional and muscle mass assessments may improve perioperative management strategies for PDAC.