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Published on: May 7, 2011
Association of IL-6-572 polymorphism with sepsis: An updated meta-analysis
Fang Hou1, Jing Gao2, Li Zhang2
1Department of Intensive Care Unit, First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.
Objectives:
To analyze the relationship between IL and 6 572C/G polymorphism with sepsis.
Methods:
Searching 8 databases the Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), Chongqing VIP, Embase, PubMed, WanFang Data, and Web of Science from inception to October 1, 2023. Meta-analysis was performed by using Review Manager 5.4 and STATA 15.0.
Results:
9 studies were included, 1 study was excluded from the previous meta-analysis, and 6 studies were added. Sensitivity analysis suggested that the results were relatively robust. The P values of Egger test indicated that no conspicuous publication bias was found.
Conclusion:
According to the meta-analysis results of existing studies, the IL-6 572C/G GG genotype and G allele are risk factors for sepsis, this result changes the previous conclusion that the IL-6 572 polymorphism is not related to sepsis. However, the results still need to be conservatively treated due to the sample size was not large enough.
