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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Immunology
  9. Immunology Not Elsewhere Classified
  11. [case Report Of Occult Breast Cancer With Triple Negative Subtype]

[Case Report of Occult Breast Cancer with Triple Negative Subtype]

Yuko Tanaka1, Yuki Ohshima, Yumi Fukaya

  • 1Division of General Thoracic Surgery, Tottori University Hospital.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|April 21, 2024

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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

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Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

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View abstract on PubMed

Summary
This summary is machine-generated.

A 61-year-old woman was diagnosed with occult breast cancer presenting as a right axillary mass. Despite extensive investigation, the primary tumor remained undetected, highlighting challenges in diagnosing this rare condition.

Area of Science:

  • Oncology
  • Diagnostic Imaging
  • Pathology

Background:

  • Occult breast cancer, defined as malignancy with no identifiable primary tumor, presents diagnostic challenges.
  • Metastasis to axillary lymph nodes can be the initial presentation of occult breast cancer.
  • Triple-negative invasive ductal carcinoma is an aggressive subtype often associated with occult primary tumors.

Observation:

  • A 61-year-old woman presented with a right axillary mass. Initial imaging (mammography, ultrasound, MRI) showed no primary breast lesion but a swollen lymph node.
  • Fine-needle aspiration cytology and core needle biopsy confirmed metastatic invasive ductal carcinoma (ER-, PgR-, HER2-).
  • Extensive whole-body examination failed to locate the primary tumor.

Findings:

  • The patient was diagnosed with right occult breast cancer based on the axillary mass and confirmed malignancy.

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  • Axillary dissection revealed metastases in only one lymph node, suggesting limited disease spread.
  • The inability to identify the primary tumor underscores the 'occult' nature of the diagnosis.

    • Implications:

    • This case highlights the importance of considering occult breast cancer in patients with isolated axillary lymph node metastasis.
    • Diagnostic and staging protocols may need refinement to improve the detection of primary tumors in such cases.
    • Multidisciplinary management, including chemotherapy and radiotherapy, is crucial for treating occult breast cancer.