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Salvage prostate intensity modulated radiation therapy after cryotherapy failure
Tanguy Perennec1, Maximilien Rogé2, Jean-François Hetet3
1Department of Radiation Oncology, Institut de Cancérologie de L'Ouest, Bd Professeur Jacques Monod, 44800, Saint-Herblain, France. tanguy.perennec@ico.unicancer.fr.
Scientific Reports
|April 21, 2024
Summary
Radiotherapy after cryotherapy for recurrent prostate cancer shows feasibility and local control. Further prospective trials are needed to confirm its efficacy and safety in clinical practice.
Area of Science:
- Urology
- Oncology
- Radiation Oncology
Background:
- Cryotherapy is a treatment for localized prostate cancer.
- Treatment options for recurrent prostate cancer after cryotherapy are not well-defined.
- Outcomes of salvage treatments for prostate cancer recurrence post-cryotherapy are largely unknown.
Purpose of the Study:
- To evaluate the feasibility and outcomes of radiotherapy in patients with recurrent prostate cancer after initial cryotherapy.
- To assess local control rates and toxicity profiles of salvage radiotherapy following cryotherapy.
Main Methods:
- Retrospective collection of patients treated with radiotherapy for local prostate cancer recurrence post-cryotherapy.
- Study conducted in Nantes, France, between 2012 and 2019.
- Analysis of treatment outcomes, including local control, toxicity, and survival, after a median follow-up of 5 years.
Main Results:
- Ten patients were identified and treated with salvage radiotherapy.
- Two patients experienced late grade 3 toxicities (rectal hemorrhage, hematuria).
- Two patients relapsed at 61 and 62 months; three patients died from other causes.
Conclusions:
- Salvage radiotherapy for localized prostate cancer recurrence after cryotherapy appears feasible and effective for local control.
- The observed toxicities and relapse rates suggest caution, but results are encouraging for future research.
- Prospective trials are warranted to further investigate this treatment strategy.
