Glucose ingestion does not lower testosterone concentrations in men on testosterone therapy
Sandeep Dhindsa1,2, Husam Ghanim2, Michael J McPhaul3
1Division of Endocrinology, Diabetes and Metabolism, Saint Louis University School of Medicine, St. Louis, MO, USA.
Summary
Oral glucose intake significantly lowers testosterone in men without therapy, but not in those undergoing testosterone treatment. This suggests fasting is crucial for hypogonadism diagnosis, not therapy monitoring.
Area of Science:
- Endocrinology
- Metabolic studies
Background:
- Oral calorie intake can acutely decrease serum testosterone levels.
- The effect of oral glucose on testosterone in men on testosterone therapy is unknown.
Purpose of the Study:
- To evaluate changes in testosterone concentrations after oral glucose ingestion in hypogonadal men before and after testosterone therapy.
Main Methods:
- A secondary analysis of samples from hypogonadal men with type 2 diabetes receiving testosterone therapy.
- Participants (n=14) ingested 75g oral glucose, with blood samples collected over 2 hours, before and after 23 weeks of testosterone therapy.
Main Results:
- Testosterone concentrations significantly decreased after glucose intake before therapy (p=0.04), with nadir at 1 hour.
- No significant change in testosterone concentrations was observed after 23 weeks of testosterone therapy.
- The decline in testosterone at 60 minutes was significantly greater before therapy compared to after (-11±10% vs 0±16%, p=0.05).
Conclusions:
- Oral glucose intake does not impact testosterone concentrations in men undergoing testosterone therapy.
- Fasting testosterone levels are necessary for diagnosing hypogonadism but not for monitoring testosterone therapy effectiveness.
More Related Videos
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
68.4K
06:59Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
10.9K
Related Concept Videos
01:15Hypoglycemia and Glucagon
257
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
257
01:16Hormones Regulating Blood Glucose
3.3K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
3.3K
01:02Glucose Homeostasis: Regulation of Blood Glucose
1.6K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
1.6K
01:19Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
174
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
174
01:26Glucose Absorption Into the Small Intestine
31.6K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
31.6K
01:26Oral Hypoglycemic Agents: Biguanides and Glitazones
195
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
195