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Recurrent Retinal Detachment in Stickler Syndrome.
Timothy Chen1, Marjan Fooladi, Michelle Alabek
1UPMC Vision Institute.
Research Square
|April 22, 2024
Summary
Recurrent retinal detachment in Stickler Syndrome patients is often caused by proliferative vitreoretinopathy early on, and new breaks later. Primary scleral buckling carries a high risk of late re-detachment.
Area of Science:
- Ophthalmology
- Genetics
- Retinal Surgery
Background:
- Stickler Syndrome is a genetic disorder associated with an increased risk of retinal detachment.
- Understanding recurrence patterns after rhegmatogenous retinal detachment (RD) repair is crucial for managing these patients.
Approach:
- This retrospective case series analyzed 30 eyes from 22 patients with Stickler Syndrome undergoing rhegmatogenous RD repair.
- Recurrence was categorized as early (within 1 year) or late (after 1 year).
- Surgical methods included pars plana vitrectomy with scleral buckling (PPV/SB), primary scleral buckling (SB), and pneumatic retinopexy (PnR).
Key Points:
- Recurrent RD occurred in 46% of PPV/SB eyes and 63% of SB eyes.
- Early recurrence was primarily linked to proliferative vitreoretinopathy (PVR).
- Late recurrence was mainly caused by new retinal breaks, sometimes posterior to the buckle.
Conclusions:
- Early recurrent RD in Stickler Syndrome is often driven by PVR.
- Late recurrent RD is frequently associated with new retinal breaks.
- Primary SB for rhegmatogenous RD in this population poses a significant risk for late re-detachment.
