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LINK-A: unveiling its functional role and clinical significance in human tumors
Bing Liao1, Jialing Wang2, Yilin Xie3
1Department of Otorhinolaryngology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Frontiers in Cell and Developmental Biology
|April 22, 2024
Summary
Long non-coding RNA LINK-A (LINC01139) is a crucial oncogene in various cancers. This review details its role in cancer progression, diagnosis, and therapeutic resistance, highlighting its potential as a target.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) play significant roles in cancer development and progression.
- LINK-A (LINC01139) is an oncogenic lncRNA frequently upregulated in diverse solid and liquid tumors.
- Its dysregulation is linked to critical cancer hallmarks and signaling pathways.
Purpose of the Study:
- To provide a comprehensive review of the molecular mechanisms and clinical significance of LINK-A in cancer.
- To explore LINK-A's role as a potential biomarker for cancer diagnosis and prognosis.
- To discuss LINK-A's involvement in therapeutic resistance and its potential as a therapeutic target.
Main Methods:
- Literature review of existing studies on LINK-A in cancer.
- Analysis of LINK-A's involvement in cancer-related signaling pathways (e.g., AKT, HIF1α).
- Examination of LINK-A's association with oncogenic activities (proliferation, apoptosis, EMT, invasion, migration, glycolysis).
Main Results:
- LINK-A is upregulated across multiple cancer types, including breast, ovarian, lung, and hematological malignancies.
- It regulates key oncogenic pathways and processes, contributing to tumor progression.
- LINK-A expression correlates with clinical features, suggesting its utility as a biomarker.
- LINK-A is implicated in resistance to therapies like AKT inhibitors and immunotherapy.
Conclusions:
- LINK-A is a significant oncogenic lncRNA with multifaceted roles in cancer.
- It holds promise as a diagnostic and prognostic biomarker for various cancers.
- Targeting LINK-A presents a potential therapeutic strategy for overcoming treatment resistance and improving cancer outcomes.
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