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Updated: Jun 28, 2025

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Is Glaucoma a Two-Pressure-Related Optic Neuropathy? A Systematic Review and Meta-Analysis
Tung Thanh Hoang1,2,3, Bui Van Anh4, Prem Subramanian5
1Hanoi Medical University, Department of Ophthalmology, Hanoi, Vietnam.
Objectives:
To review the current literature related to the correlation between translaminar pressure difference (TLPD) and glaucoma.
Materials And Methods:
In this article, we conducted a literature review using MEDLINE via PubMed, Cochrane Eyes and Vision, and Google Scholar from 01/01/2010 to 31/12/2022. Search terms included "glaucoma", "intraocular pressure", "translaminar cribrosa pressure gradient/difference", "intracranial pressure", and "cerebrospinal fluid pressure". Of 471 results, 8 articles were selected for the meta-analysis.
Results:
Our meta-analysis demonstrated significantly higher intraocular pressure, lower cerebrospinal fluid pressure (CSFp), and greater TLPD in high-tension and normal-tension glaucoma groups compared to healthy groups.
Conclusion:
The differences in CSFp and TLPD between glaucoma and healthy people detected in current studies suggests a potential relationship between TLPD and glaucoma.
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