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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
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pH-responsive i-motif-conjugated nanoparticles for MRI analysis.

Kristine Y Ma1,2, Mireia Perera-Gonzalez2, Nicole I Langlois3

  • 1School of Biological and Health Systems Engineering, Arizona State University Tempe AZ USA Heather.Ann.Clark@asu.edu.

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|April 22, 2024
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Summary
This summary is machine-generated.

Researchers developed a novel pH-responsive MRI contrast agent using DNA nanostructures and Gadolinium. This agent shows significant signal changes in response to pH variations, enabling new possibilities for bioimaging.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Molecular Imaging

Background:

  • Gadolinium (Gd)-based contrast agents (CAs) are crucial for enhancing anatomical details in magnetic resonance imaging (MRI).
  • Bioresponsive CAs are being developed to monitor biochemical processes like pH.
  • Modulating MRI signals based on rotational correlation time (τR) offers a new avenue for CA development.

Purpose of the Study:

  • To introduce a novel pH-responsive MRI contrast agent using DNA nanostructures.
  • To modulate MRI signals by controlling the rotational correlation time (τR) of the contrast agent.
  • To develop a dynamic, programmable DNA-based complex for bioresponsive MRI.

Main Methods:

  • Combined a pH-responsive oligonucleotide (i-motif) with a clinical standard CA (Gd-DOTA).
  • Incorporated the i-motif onto gold nanoparticles (iM-GNP) to create the pH-responsive CA.
  • Evaluated the relaxivity (r1) changes of iM-GNP across a decreasing pH range (7.5-4.5) in vitro and in human serum.

Main Results:

  • The iM-GNP demonstrated increased relaxivity (r1) under acidic conditions, with a calculated pKa = 5.88 ± 0.01.
  • A significant pH-dependent signal change of 16.7% per 0.1 pH unit was observed.
  • In 20% human serum, iM-GNP showed a 28.14 ± 11.2% signal increase from neutral to acidic pH, unlike a control CA.

Conclusions:

  • The developed DNA-based nanostructure effectively modulates MRI signals in response to pH changes.
  • This approach offers a new strategy for creating programmable, dynamic, and bioresponsive MRI contrast agents.
  • The findings pave the way for advanced MRI applications in monitoring biochemical processes.