PGS/Gelatin Nanocomposite Electrospun Wound Dressing.

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Wound Healing

Background:

• Infectious diabetic wounds pose significant health risks, necessitating advanced wound care solutions.
• Developing biocompatible wound dressings with optimal hydrophilicity and degradation rates remains a challenge.

Purpose of the Study:

• To create and characterize a novel electrospun wound dressing scaffold composed of poly(glycerol sebacate) (PGS) and gelatin (Gel).
• To evaluate the hydrophilicity, porosity, and biocompatibility of the developed PGS/Gel scaffold for potential wound healing applications.

Main Methods:

• Electrospinning was employed to fabricate PGS/Gel scaffolds using acetic acid as a solvent and EDC/NHS as a crosslinking agent.
• Scaffold characterization included fiber diameter measurement, porosity assessment, and contact angle analysis.
• In vitro cell viability assays were performed to evaluate cell growth and proliferation on the scaffolds.

Main Results:

• The PGS/Gel scaffolds exhibited fiber diameters ranging from 180.2 to 370.6 nm with porosity exceeding 70%.
• A significant decrease in contact angle (from 110.8° ± 4.3° to 54.9° ± 2.1°) indicated enhanced hydrophilicity of the PGS/Gel blend.
• Cell viability assays showed a significant increase in cell growth and proliferation on the scaffolds.

Conclusions:

• The electrospun PGS/Gel scaffold demonstrates favorable physical properties, including suitable porosity and enhanced hydrophilicity.
• The scaffold supports cell viability and proliferation, suggesting its potential as a promising biomaterial for treating infectious diabetic wounds.