Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structured Educational Tours in Hospital-Based Radiopharmaceutical Production: Balancing Safety and Learning.

Journal of nuclear medicine technology·2026
Same author

Neural circuits of torpor.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·2026
Same author

Immobilized laccase reactors for process intensification: Kinetic comparison of batch and continuous-flow systems.

Journal of biotechnology·2026
Same author

GABAergic projections from the suprachiasmatic nucleus to the preoptic area regulate the timing of torpor in mice.

Nature communications·2026
Same author

Selective and differential roles of PVH<sup>CRH</sup> neurotransmitters in diet-induced obesity in mice.

Nature communications·2026
Same author

Quantitative characterization of torpor-associated behaviors in mice.

iScience·2026

Related Experiment Video

Updated: Jun 28, 2025

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

12.7K

Malignant syphilis requiring differentiation from Kaposi's sarcoma.

Mieko Tokano1,2, Norihito Tarumoto1, Kazuo Imai1

  • 1Department of Infectious Disease and Infection Control, Saitama Medical University, 38 Morohongo, Moroyama, Saitama 350-0495, Japan.

Idcases
|April 22, 2024
PubMed
Summary

Malignant syphilis (MS), a rare form of secondary syphilis, presents with distinctive black-crusted lesions. This case highlights MS in an HIV-infected individual with atypical facial lesions, emphasizing diagnostic considerations.

Keywords:
Atypical cutaneous lesionsHIV infectionKaposi's sarcomaMalignant syphilisRupioid syphilisSecondary syphilis

More Related Videos

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
09:53

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

8.3K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

1.9K

Related Experiment Videos

Last Updated: Jun 28, 2025

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

12.7K
An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
09:53

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

8.3K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

1.9K

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Syphilology

Background:

  • Malignant syphilis (MS), also known as rupioid syphilis, is an uncommon manifestation of secondary syphilis.
  • MS typically presents with ulcerated, crusted lesions and is frequently associated with immunodeficiency, particularly HIV infection.

Purpose of the Study:

  • To report a case of malignant syphilis in an HIV-infected patient.
  • To highlight the diagnostic challenges posed by atypical clinical presentations of MS.
  • To underscore the importance of considering MS in patients with characteristic crusting lesions.

Main Methods:

  • Case report of a patient with HIV infection presenting with atypical cutaneous lesions.
  • Clinical evaluation of skin manifestations.
  • Laboratory confirmation of syphilis.
  • Observation of the Jarisch-Herxheimer reaction and response to antibiotic therapy.

Main Results:

  • The patient presented with malignant syphilis, characterized by black, lamellate crusting lesions predominantly on the face.
  • Clinical presentation was atypical, with lesions limited to the face, complicating initial diagnosis.
  • Laboratory findings, the Jarisch-Herxheimer reaction, and a positive response to antibiotics confirmed the diagnosis of MS.

Conclusions:

  • HIV infection can lead to atypical clinical presentations of malignant syphilis.
  • Physicians should consider malignant syphilis in the differential diagnosis of patients presenting with black-crusted lesions, even with limited or atypical lesion distribution.
  • Early diagnosis and appropriate antibiotic treatment are crucial for managing malignant syphilis.