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Dinuclear NHC-gold(I)-thiolato and -alkynyl complexes: synthesis, anticancer activity, and catalytic activity in
Xinyuan Ma1,2, Yuan Zhao1, Isabella Caligiuri3
1Department of Chemistry, Centre for Sustainable Chemistry, Ghent University, Krijgslaan 281, S3, 9000 Ghent, Belgium. steven.nolan@ugent.be.
Abstract:
A series of novel dinuclear NHC-gold-thiolato and -alkynyl complexes bearing aromatic linkers were successfully synthesized by an efficient and simple synthetic route. The catalytic activity of these complexes was tested in a lactonization reaction. The reaction proceeds in high efficiency, in short reaction time and under mild conditions, and is complementary to existing methods. Furthermore, the digold(I)-thiolato derivatives exhibit remarkable cytotoxicity towards several cancer cell lines.
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