Amyloid detection in neurodegenerative diseases using MOFs
Ketan Maru1, Amarendra Singh1, Ritambhara Jangir1
1Sardar Vallabhbhai National Institute of Technology, Ichchanath, Surat-395 007, Gujarat, India. ritambhara.jangir@chem.svnit.ac.in.
Journal of Materials Chemistry. B
|April 22, 2024
Summary
Metal-organic frameworks (MOFs) offer advanced detection for amyloid diseases like Alzheimer's and Parkinson's. These novel biosensors show promise for early diagnosis and improved management of neurodegenerative conditions.
Area of Science:
- Materials Science
- Biotechnology
- Neuroscience
Background:
- Neurodegenerative diseases, including Alzheimer's and Parkinson's, are characterized by protein misfolding and aggregation.
- Early detection of amyloid diseases is critical due to their severe systemic implications, organ dysfunction, and high mortality rates.
- Traditional diagnostic methods rely on imaging or invasive procedures, necessitating the development of advanced detection techniques.
Purpose of the Study:
- To review the application of metal-organic frameworks (MOFs) in detecting amyloid diseases.
- To explore how MOFs, integrated into biosensors, can revolutionize the early diagnosis and management of neurodegenerative disorders.
- To categorize MOF-based sensing strategies for amyloid detection.
Main Methods:
- Review of existing literature on MOF applications in biosensing for amyloid diseases.
- Categorization of MOF biosensors based on sensing mechanisms: electrochemical (EC), electrochemiluminescence (ECL), fluorescence, Förster resonance energy transfer (FRET), up-conversion luminescence resonance energy transfer (ULRET), and photoelectrochemical (PEC).
- Discussion of the properties of MOFs, including porosity, structural tunability, and biocompatibility, that facilitate biosensor development.
Main Results:
- MOFs enable the development of highly sensitive and specific biosensors for detecting amyloid species.
- Various MOF-based sensing techniques (EC, ECL, fluorescence, FRET, ULRET, PEC) have been successfully employed for amyloid detection.
- MOFs offer precise detection and quantification of amyloid proteins, advancing early diagnosis and disease management.
Conclusions:
- MOFs represent a promising platform for developing next-generation biosensors for amyloid diseases.
- MOF-based biosensors offer significant advantages over traditional methods for early and accurate diagnosis.
- Further research into MOF biosensors could overcome current limitations and challenges in the field.
