Clinicopathological role of Cyclin A2 in uterine corpus endometrial carcinoma: Integration of tissue microarrays and
Wei-Jia Mo1, Zi-Qian Liang1, Jie-Zhuang Huang1
1Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
The International Journal of Biological Markers
|April 22, 2024
Summary
Cyclin A2 (CCNA2) is elevated in uterine corpus endometrial carcinoma (UCEC), primarily in T and B cells. Its overexpression indicates a poorer prognosis for UCEC patients.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- The expression and function of Cyclin A2 (CCNA2) in uterine corpus endometrial carcinoma (UCEC) are not well understood.
- Investigating CCNA2 is crucial for understanding UCEC pathogenesis.
Purpose of the Study:
- To determine the expression level of CCNA2 in UCEC.
- To identify CCNA2's molecular role and prognostic significance in UCEC.
- To explore CCNA2's activity in different cell types within UCEC.
Main Methods:
- Analysis of CCNA2 protein and mRNA expression in UCEC and normal tissues using in-house and public data.
- Identification of CCNA2 transcription factors via the Cistrome database.
- Prognostic evaluation using Cox regression and Kaplan-Meier analysis.
- Single-cell RNA sequencing (scRNA-seq) and AUCell algorithm for cell-type-specific CCNA2 activity.
Main Results:
- CCNA2 expression was significantly upregulated in UCEC tissues compared to normal controls.
- E2F1 and FOXM1 were identified as transcription factors regulating CCNA2.
- CCNA2 overexpression was associated with a worse prognosis in UCEC patients.
- scRNA-seq revealed CCNA2 expression and activity predominantly in T cells and B cells within UCEC.
Conclusions:
- CCNA2 is overexpressed in UCEC and localized mainly within T and B lymphocytes.
- Elevated CCNA2 levels are linked to an unfavorable prognosis in UCEC.
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