Altenuene derivatives produced by an endophyte Alternaria alternata
Reo Takahashi1, Shin-Nosuke Isshiki1, Mayuka Hakozaki2
1Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Japan.
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Two novel aromatic polyketides 1 and 3 and five known compounds, (4S,10S)-talaroflavone (2), altenuene (4), isoaltenuene (5), alternariol (6), and altenusin (7), were isolated from an endophytic strain of Alternaria alternata SI-694. The structures of the new compounds, including their absolute configurations, were elucidated by NMR, IR, UV, and ECD spectroscopies, and the phytotoxicities of the isolated compounds were also evaluated. Altenusin (7) showed moderate cytotoxicity against HL-60 cells, with an IC50 of 6.65 µM, whereas 5, 6, and 7 were phytotoxic against Lactuca sativa, Brassica campestris L., Stellaria aquatica (L.) Scop. and Digitaria ciliaris.
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