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YiQi GuBen capsule alleviates OVA-induced asthma through improving mitochondrial dysfunction
Xiaoting Ren1, Yibu Kong2, Hongjun Yu2
1College of Traditional Chinese Medicine, Changchun University of Chinese Medical, Changchun, China.
Summary
YiQi GuBen capsule treatment significantly reduced lung tissue damage and improved mitochondrial dysfunction in an asthma mouse model. This traditional Chinese medicine enhanced mitochondrial structure and function, offering a potential therapeutic approach for asthma.
Area of Science:
- Mitochondrial Biology
- Pulmonology
- Pharmacology
Background:
- Asthma is characterized by airway inflammation and often involves mitochondrial dysfunction.
- Mitochondrial dysfunction contributes to the pathogenesis of asthma, impacting cellular energy production and oxidative stress.
- Traditional Chinese Medicine (TCM) formulations are being investigated for their therapeutic potential in various diseases, including asthma.
Purpose of the Study:
- To investigate the efficacy of YiQi GuBen capsule in ameliorating mitochondrial dysfunction in a mouse model of asthma.
- To evaluate the impact of YiQi GuBen capsule on lung tissue pathology and mitochondrial ultrastructure in ovalbumin-induced asthma.
Main Methods:
- Establishment of an ovalbumin (OVA)-induced asthma mouse model.
- Treatment groups included control, OVA, dexamethasone (OVA+DEX), and YiQi GuBen capsule (OVA+YQGB).
- Histopathological analysis (HE and Masson staining), transmission electron microscopy (TEM), flow cytometry (ROS, membrane potential, mitochondrial number), mitochondrial DNA (mtDNA) copy number analysis, and Western blotting for PGC-1α and TFAM expression.
Main Results:
- YiQi GuBen capsule treatment significantly reduced lung tissue damage and improved mitochondrial ultrastructural integrity.
- Flow cytometry revealed reduced reactive oxygen species (ROS) levels, increased mitochondrial number, and altered membrane potential in treated mice.
- Increased mtDNA copy number and elevated expression of PGC-1α and TFAM were observed, indicating enhanced mitochondrial biogenesis and function.
Conclusions:
- YiQi GuBen capsule demonstrates significant therapeutic effects in improving mitochondrial dysfunction associated with asthma.
- The findings suggest that YiQi GuBen capsule can protect lung tissue and restore mitochondrial health in an OVA-induced asthma model.
- YiQi GuBen capsule represents a promising therapeutic agent for managing asthma by targeting mitochondrial dysfunction.
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