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Current advances for omics-guided process optimization of microbial manufacturing.

Shengtong Wan1, Xin Liu2,3,4, Wentao Sun5,6,7

  • 1Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology, Institute of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, People's Republic of China.

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Omics technologies enhance microbial manufacturing by optimizing processes, moving beyond traditional methods. This approach boosts productivity and economic viability for sustainable production.

Keywords:
Fermentation performanceMicrobial manufacturingOmicsProcess optimization

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Area of Science:

  • Biotechnology and Industrial Microbiology
  • Metabolic Engineering
  • Fermentation Science

Background:

  • Microbial manufacturing is crucial for sustainable production in food, medicine, and energy sectors.
  • Current process optimization relies on experience and trial-and-error, limiting productivity and economic feasibility.
  • Understanding cellular physiology is key to unlocking full production potential.

Purpose of the Study:

  • To systematically review traditional and omics technologies-guided process optimization in microbial manufacturing.
  • To highlight the benefits of omics technologies for enhancing microbial production performance.
  • To prospect future trends in microbial manufacturing process optimization.

Main Methods:

  • Review of traditional, experience-based process optimization techniques.
  • Analysis of omics technologies (genomics, transcriptomics, proteomics, metabolomics) for microbial analysis.
  • Integration of multi-level omics data for informed process optimization.

Main Results:

  • Omics technologies enable comprehensive analysis of microbial metabolism and fermentation.
  • Data-driven optimization using omics significantly improves microbial manufacturing performance.
  • This approach overcomes limitations of traditional methods, boosting productivity and economic benefits.

Conclusions:

  • Omics technologies provide a more explicit and effective approach to microbial manufacturing process optimization.
  • Integrating omics data is essential for maximizing productivity and achieving economic feasibility.
  • Future trends point towards advanced omics integration for sustainable and efficient microbial production.