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Biomarker-oriented chemo-immunotherapy for advanced gastric cancer

Koji Kono1, Shotaro Nakajima2,3, Kosaku Mimura2,4

  • 1Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, 960-1295, Japan. kojikono@fmu.ac.jp.

International Journal of Clinical Oncology
|April 22, 2024
PubMed

Insights

Biomarker-driven therapies are advancing gastric cancer treatment. This review highlights key biomarkers like HER2, PD-L1, and Claudin18.2 for targeted anticancer drug development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Biomarker-oriented chemo-immunotherapy shows promise for anticancer drug development by enriching patient responders.
  • Development of biomarker-driven therapeutics for gastric cancer has lagged compared to other cancers like colorectal and lung.
  • Recent discoveries and clinical trials are advancing targeted therapies for gastric cancer.

Purpose of the Study:

  • To review significant biomarkers in gastric cancer.
  • To discuss the clinical significance of these biomarkers.
  • To highlight associated targeted therapeutic agents.

Main Methods:

  • Literature review of recent studies on gastric cancer biomarkers.
  • Analysis of clinical trial data for biomarker-driven therapies.
  • Focus on human epidermal growth factor receptor 2 (HER2), programmed death-ligand 1 (PD-L1), and Claudin18.2.

Main Results:

  • HER2, PD-L1, and Claudin18.2 are key biomarkers in gastric cancer.
  • These biomarkers have demonstrated clinical significance in patient stratification.
  • Targeted agents associated with these biomarkers offer new treatment options.

Conclusions:

  • Individualized, biomarker-oriented strategies are becoming viable for gastric cancer treatment.
  • Targeted therapies based on HER2, PD-L1, and Claudin18.2 represent a promising frontier.
  • Continued research in biomarker discovery and targeted agents is crucial for advancing gastric cancer care.
Keywords:
BiomarkerChemotherapyGastric cancerImmunotherapy

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